Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity.

@article{Yang2013ArginaseRR,
  title={Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity.},
  author={Jiangning Yang and Adrian Thomas Gonon and Per-Ove Sj{\"o}quist and Jon O N Lundberg and John Pernow},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 37},
  pages={15049-54}
}
The theory that red blood cells (RBCs) generate and release nitric oxide (NO)-like bioactivity has gained considerable interest. However, it remains unclear whether it can be produced by endothelial NO synthase (eNOS), which is present in RBCs, and whether NO can escape scavenging by hemoglobin. The aim of this study was to test the hypothesis that arginase reciprocally controls NO formation in RBCs by competition with eNOS for their common substrate arginine and that RBC-derived NO is… CONTINUE READING