Arginase modulates nitric oxide production in activated macrophages.

  title={Arginase modulates nitric oxide production in activated macrophages.},
  author={C I Chang and James C. Liao and L Kuo},
  journal={The American journal of physiology},
  volume={274 1 Pt 2},
In macrophages and many other cell types, L-arginine is used as a substrate by both nitric oxide synthase (NOS) and arginase to produce nitric oxide (NO) and urea, respectively. Because the availability of L-arginine is a major determinant for NO synthesis in the activated macrophage, we hypothesized that NO production may be reduced by arginase via depleting the common substrate in this cell type. To test this hypothesis, we investigated the effect of an arginase inhibitor, L-norvaline, on NO… CONTINUE READING

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