Arginase activity is inhibited by L-NAME, both in vitro and in vivo.

@article{Reisser2002ArginaseAI,
  title={Arginase activity is inhibited by L-NAME, both in vitro and in vivo.},
  author={Dani{\`e}le Reisser and Nathalie Onier-Cherix and J C Jeannin},
  journal={Journal of enzyme inhibition and medicinal chemistry},
  year={2002},
  volume={17 4},
  pages={267-70}
}
The present study investigated the ability of the arginine analog L-NAME (N(omega)-Nitro-L-arginine methyl ester) to modulate the activity of arginase. L-NAME inhibited the activity of arginase in lysates from rat colon cancer cells and liver. It also inhibited the arginase activity of tumor cells in culture. Furthermore, in vivo treatment of rats with L-NAME inhibited arginase activity in tumor nodules and liver, and the effect persisted after treatment ceased. The effect of L-NAME on arginase… CONTINUE READING

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