Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation

@inproceedings{Cherry2015Arginase1M,
  title={Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation},
  author={Jonathan D Cherry and John A. Olschowka and M. Kerry O’Banion},
  booktitle={Journal of Neuroinflammation},
  year={2015}
}
Neuroinflammation has long been considered a driver of Alzheimer’s disease progression. However, experiments developed to explore the interaction between neuroinflammation and Alzheimer’s disease (AD) pathology showed a surprising reduction in amyloid beta (Aβ) plaque deposition. We sought to understand this unexpected outcome by examining microglia phenotypes during chronic neuroinflammation. Using an adeno-associated virus vector carrying hIL-1β cDNA, inflammation was induced in one… CONTINUE READING
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