Argatroban in heparin-induced thrombocytopenia: rationale for use and place in therapy.

  title={Argatroban in heparin-induced thrombocytopenia: rationale for use and place in therapy.},
  author={Ramandeep K. Bambrah and Dat Cao Pham and Fauzia N Rana},
  journal={Therapeutic advances in chronic disease},
  volume={4 6},
Heparin-induced thrombocytopenia (HIT) is a recognized complication of heparin and requires urgent detection and treatment. HIT can be divided into two types, type I and type II, with type I being a transient decrease in platelet count without clinical consequence. For the purpose of this review, the term HIT refers to the immune-mediated type II that causes paradoxical thrombo-emboli. The aim of this review is to familiarize clinicians with a specific direct thrombin inhibitor, argatroban, in… CONTINUE READING
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