Argatroban for anticoagulation in continuous renal replacement therapy.

@article{Link2009ArgatrobanFA,
  title={Argatroban for anticoagulation in continuous renal replacement therapy.},
  author={Andreas Link and Matthias Girndt and Simina Selejan and Alexander Mathes and Michael B{\"o}hm and Hauke Rensing},
  journal={Critical care medicine},
  year={2009},
  volume={37 1},
  pages={105-10}
}
OBJECTIVE Argatroban, a direct thrombin inhibitor, was evaluated for anticoagulation in continuous renal replacement therapy (CRRT) in critically ill patients with heparin-induced thrombocytopenia type II and acute renal failure. The investigation focused on predictors for the maintenance doses of argatroban with efficacy and safety of argatroban being secondary outcomes. DESIGN Prospective, dose finding study. SETTING Two intensive care units (medical and surgical) of a university hospital… CONTINUE READING