Argatroban anticoagulation in patients with acute ischemic stroke (ARGIS-1): a randomized, placebo-controlled safety study.

@article{Lamonte2004ArgatrobanAI,
  title={Argatroban anticoagulation in patients with acute ischemic stroke (ARGIS-1): a randomized, placebo-controlled safety study.},
  author={Marian P Lamonte and Marshall L Nash and David Z. W. Wang and Andrew R Woolfenden and John Schultz and Marcie J. Hursting and Philip M Brown},
  journal={Stroke},
  year={2004},
  volume={35 7},
  pages={1677-82}
}
BACKGROUND AND PURPOSE Direct thrombin inhibitors, including argatroban, represent an anticoagulant class distinct from heparins. We investigated the safety of 2 levels of argatroban anticoagulation in acute ischemic stroke. METHODS This multicenter, randomized, double-blinded, placebo-controlled study included 171 patients with acute (< or =12 hours from onset) stroke and National Institutes of Health Stroke Scale (NIHSS) scores of 5 to 22. Patients received continuous intravenous argatroban… CONTINUE READING
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