Argatroban: update.

@article{Yeh2006ArgatrobanU,
  title={Argatroban: update.},
  author={Robert W Yeh and Ik Kyung Jang},
  journal={American heart journal},
  year={2006},
  volume={151 6},
  pages={1131-8}
}
Unfractionated heparin has historically been used as the anticoagulant of choice in the management of a number of thrombotic diseases. Recognition of the limitations of heparin has led to the development of a newer class of anticoagulants, the direct thrombin inhibitors. Argatroban is a synthetic small molecule that selectively inhibits thrombin at its active site. In preclinical studies, argatroban has been shown to be more effective than heparin in preventing arterial thrombosis and in… CONTINUE READING
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