Arg753Gln TLR-2 polymorphism in familial mediterranean fever: linking the environment to the phenotype in a monogenic inflammatory disease.

@article{Ozen2006Arg753GlnTP,
  title={Arg753Gln TLR-2 polymorphism in familial mediterranean fever: linking the environment to the phenotype in a monogenic inflammatory disease.},
  author={Seza Ozen and Afig Huseyinov Berdeli and Banu T{\"u}rel and Sim Kutlay and Fatoş Yalçinkaya and Mustafa Arici and Nesrin Beşbaş and Aysin S Bakkaloglu and Engin Yilmaz},
  journal={The Journal of rheumatology},
  year={2006},
  volume={33 12},
  pages={2498-500}
}
OBJECTIVE Familial Mediterranean fever (FMF) is an autoinflammatory disease common in eastern Mediterranean populations. The most severe complication is the development of secondary amyloidosis. Toll-like receptor (TLR-2) plays a critical role in linking the recognition of microbes to immune activation. We investigated whether the Arg753Gln TLR2 polymorphism affected the development of secondary amyloidosis in patients with FMF. METHODS We studied 75 patients with FMF, 40 patients with FMF… CONTINUE READING

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