Arf6 regulates EGF-induced internalization of E-cadherin in breast cancer cells

@inproceedings{Xu2015Arf6RE,
  title={Arf6 regulates EGF-induced internalization of E-cadherin in breast cancer cells},
  author={Rui Xu and Yujie Zhang and Luo Gu and Jianchao Zheng and Jie Cui and Jing Dong and Jun Du},
  booktitle={Cancer Cell International},
  year={2015}
}
E-cadherin internalization facilitates dissolution of adherens junctions and promotes tumor cell epithelial-mesenchymal transition (EMT) and migration. Our previous results have shown that Arf6 exerts pro-migratory action in breast cancer cells after EGF stimulation. Despite the fact that EGF signaling stimulates EMT of breast cancer cells, the effect of Arf6 on internalization of E-cadherin of breast cancer cells under EGF treatment remains to be determined. Here, we showed that EGF dose… CONTINUE READING
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