Arf6-independent GPI-anchored protein-enriched early endosomal compartments fuse with sorting endosomes via a Rab5/phosphatidylinositol-3'-kinase-dependent machinery.

@article{Kalia2006Arf6independentGP,
  title={Arf6-independent GPI-anchored protein-enriched early endosomal compartments fuse with sorting endosomes via a Rab5/phosphatidylinositol-3'-kinase-dependent machinery.},
  author={Manjula Kalia and Sudha Kumari and Rahul Chadda and Michelle M. Hill and Robert G. Parton and Satyajit Mayor},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 8},
  pages={
          3689-704
        }
}
In the process of internalization of molecules from the extracellular milieu, a cell uses multiple endocytic pathways, consequently generating different endocytic vesicles. These primary endocytic vesicles are targeted to specific destinations inside the cell. Here, we show that GPI-anchored proteins are internalized by an Arf6-independent mechanism into GPI-anchored protein-enriched early endosomal compartments (GEECs). Internalized GPI-anchored proteins and the fluid phase are first… CONTINUE READING

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