Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells.

@article{Humphreys2013Arf6CA,
  title={Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells.},
  author={Daniel E Humphreys and Anthony C. Davidson and Peter J. Hume and Laura E Makin and Vassilis Koronakis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 42},
  pages={16880-5}
}
ADP ribosylation factor (Arf) 6 anchors to the plasma membrane, where it coordinates membrane trafficking and cytoskeleton remodelling, but how it assembles actin filaments is unknown. By reconstituting membrane-associated actin assembly mediated by the WASP family veroprolin homolog (WAVE) regulatory complex (WRC), we recapitulated an Arf6-driven actin polymerization pathway. We show that Arf6 is divergent from other Arf members, as it was incapable of directly recruiting WRC. We demonstrate… CONTINUE READING

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