Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts

@article{Balasubramanian2007Arf6AM,
  title={Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts},
  author={Nagaraj Balasubramanian and David G. W. Scott and J David Castle and James E. Casanova and Martin A Schwartz},
  journal={Nature Cell Biology},
  year={2007},
  volume={9},
  pages={1381-1391}
}
Integrin-mediated adhesion regulates membrane binding sites for Rac1 within lipid rafts. Detachment of cells from the substratum triggers the clearance of rafts from the plasma membrane through caveolin-dependent internalization. The small GTPase Arf6 and microtubules also regulate Rac-dependent cell spreading and migration, but the mechanisms are poorly understood. Here we show that endocytosis of rafts after detachment requires F-actin, followed by microtubule-dependent trafficking to… CONTINUE READING

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contentious only from simplistic standpoints

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