Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts

  title={Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts},
  author={Nagaraj Balasubramanian and David G. W. Scott and J David Castle and James E. Casanova and Martin A Schwartz},
  journal={Nature Cell Biology},
Integrin-mediated adhesion regulates membrane binding sites for Rac1 within lipid rafts. Detachment of cells from the substratum triggers the clearance of rafts from the plasma membrane through caveolin-dependent internalization. The small GTPase Arf6 and microtubules also regulate Rac-dependent cell spreading and migration, but the mechanisms are poorly understood. Here we show that endocytosis of rafts after detachment requires F-actin, followed by microtubule-dependent trafficking to… CONTINUE READING


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contentious only from simplistic standpoints

Hancock, J. F. Lipid rafts
Nature Rev. Mol. Cell Biol. 7, 456–462 • 2006

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