Arf and p53 act as guardians of a quiescent cellular state by protecting against immortalization of cells with stable genomes.

@article{Osawa2013ArfAP,
  title={Arf and p53 act as guardians of a quiescent cellular state by protecting against immortalization of cells with stable genomes.},
  author={Tomoyuki Osawa and Yuko Atsumi and Eiji Sugihara and Hideyuki Saya and Masamoto Kanno and Fumio Tashiro and Mitsuko Masutani and Ken-ichi Yoshioka},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={432 1},
  pages={34-9}
}
Normal cells undergo a growth-arrested status that is produced by p53-dependent down-regulation of histone H2AX. Immortality is developed after abrogation of the H2AX-diminished state, which is associated with genomic instability (often with tetraploidy) and the induction of mutations in either the Arf or p53 gene. However, the role of Arf in control of H2AX expression and genome stability is still unclear. Here, we show that both Arf and p53 are required for the down-regulation of H2AX and… CONTINUE READING

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