Arf 6 : a new player in Fc RIIIA lymphocyte-mediated cytotoxicity

  title={Arf 6 : a new player in Fc RIIIA lymphocyte-mediated cytotoxicity},
  author={Ricciarda Galandrini and Federica Micucci and Ilaria Tassi and Maria Grazia Cifone and Benedetta Cinque and M Beretta Piccoli and Luigi Frati and Angela Santoni},
The activation of phosphoinositide metabolism represents a critical step in the signaling pathways leading to the activation of cytolytic machinery, but its regulation is partially understood. We report here that the stimulation of the lowaffinity receptor for immunoglobulin G (IgG) (Fc RIIIA, CD16) on primary human natural killer (NK) cells induces a phosphatidylinositol 3-kinase (PI3K)– dependent activation of the small G protein Arf6. We first demonstrate a functional role for Arf6-dependent… CONTINUE READING


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