Arenarol isolated from a marine sponge abrogates endothelin-1-stimulated melanogenesis by interrupting MEK phosphorylation in normal human melanocytes

@article{Choi2013ArenarolIF,
  title={Arenarol isolated from a marine sponge abrogates endothelin-1-stimulated melanogenesis by interrupting MEK phosphorylation in normal human melanocytes},
  author={Bong-Keun Choi and Byung-Yoon Cha and Takeshi Fujiwara and A. Kanamoto and J. Woo and M. Ojika and G. Imokawa},
  journal={Cytotechnology},
  year={2013},
  volume={65},
  pages={915-926}
}
  • Bong-Keun Choi, Byung-Yoon Cha, +4 authors G. Imokawa
  • Published 2013
  • Biology, Medicine
  • Cytotechnology
  • Using B16 melanoma cells for screening, we found that a marine sponge extract has a potent anti-pigmenting effect and identified arenarol as its major active compound. In normal human melanocytes (NHMs), arenarol significantly abrogated the endothelin 1 (EDN1) stimulated expression of tyrosinase, tyrosinase-related protein 1 and dopachrome tautomerase at the transcriptional, translational and enzymatic activity (only for tyrosinase) levels. That effect was accompanied by the attenuation of the… CONTINUE READING
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