Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential.

@article{Chang2001ArecaNE,
  title={Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential.},
  author={M. Chang and Y. Ho and P. H. Lee and C. Chan and J. Lee and L. Hahn and Y. J. Wang and J. Jeng},
  journal={Carcinogenesis},
  year={2001},
  volume={22 9},
  pages={
          1527-35
        }
}
There are 600 million betel quid (BQ) chewers in the world. BQ chewing is a major etiologic factor of oral cancer. Areca nut (AN) and arecoline may inhibit the growth of oral mucosal fibroblasts (OMF) and keratinocytes. In this study, AN extract (100-800 microg/ml) and arecoline (20-120 microM) inhibited the growth of oral KB cells by 36-90 and 15-75%, respectively. Exposure to arecoline (> 0.2 mM) for 24 h induced G(2)/M cell cycle arrest of OMF and KB cells. Areca nut extract (> 400 microg/ml… Expand
Arecoline induced cell cycle arrest, apoptosis, and cytotoxicity to human endothelial cells
Reactive oxygen species are crucial for hydroxychavicol toxicity toward KB epithelial cells
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