Areamyloiddiseases causedbyproteinaggregates thatmimicbacterial pore-forming toxins ?

@inproceedings{Lashuel2006AreamyloiddiseasesCT,
  title={Areamyloiddiseases causedbyproteinaggregates thatmimicbacterial pore-forming toxins ?},
  author={Hilal A Lashuel and P. T. Jun. Lansbury},
  year={2006}
}
Protein fibrillization is implicated in the pathogenesis of most, if not all, ageassociated neurodegenerative diseases, but the mechanism(s) by which it triggers neuronal death is unknown. Reductionist in vitro studies suggest that the amyloid protofibril may be the toxic species and that it may amplify itself by inhibiting proteasome-dependent protein degradation. Although its pathogenic target has not been identified, the properties of the protofibril suggest that neurons could be killed by… CONTINUE READING

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