Area postrema neurons are modulated by the adipocyte hormone adiponectin.

  title={Area postrema neurons are modulated by the adipocyte hormone adiponectin.},
  author={Mark Fry and Pauline M. Smith and Ted Donald Hoyda and Marnie Duncan and Rexford S. Ahima and Keith A Sharkey and Alastair V Ferguson},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={26 38},
Adiponectin is an adipocyte-derived peptide hormone involved in energy homeostasis and the pathogenesis of obesity, including hypertension. Area postrema (AP) lacks a blood-brain barrier and is a critical homeostatic integration center for humoral and neural signals. Here we investigate the role of AP in adiponectin signaling. We show that rat AP expresses AdipoR1 and AdipoR2 adiponectin receptor mRNA. We used current-clamp electrophysiology to investigate whether adiponectin influenced… CONTINUE READING