Are women more susceptible than men to drug-induced QT prolongation? Concentration-QTc modelling in a phase 1 study with oral rac-sotalol.

@article{Darpo2014AreWM,
  title={Are women more susceptible than men to drug-induced QT prolongation? Concentration-QTc modelling in a phase 1 study with oral rac-sotalol.},
  author={Borje Darpo and Dilip R. Karnad and Fabio Badilini and Jeff Florian and Christine Garnett and Snehal Kothari and Gopi Krishna Panicker and Nenad Sarapa},
  journal={British journal of clinical pharmacology},
  year={2014},
  volume={77 3},
  pages={522-31}
}
AIM To study the differences in QTc interval on ECG in response to a single oral dose of rac-sotalol in men and women. METHODS Continuous 12-lead ECGs were recorded in 28 men and 11 women on a separate baseline day and following a single oral dose of 160 mg rac-sotalol on the following day. ECGs were extracted at prespecified time points and upsampled to 1000 Hz and analyzed manually in a central ECG laboratory on the superimposed median beat. Concentration-QTc analyses were performed using a… CONTINUE READING
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