Are treatment targets for hypercholesterolemia evidence based? Systematic review and meta-analysis of randomised controlled trials

@article{Lebenthal2010AreTT,
  title={Are treatment targets for hypercholesterolemia evidence based? Systematic review and meta-analysis of randomised controlled trials},
  author={Y. Lebenthal and A. Horv{\'a}th and P. Dziechciarz and H. Szajewska and R. Shamir},
  journal={Archives of Disease in Childhood},
  year={2010},
  volume={95},
  pages={673 - 680}
}
Objective Search for evidence supporting target age, level of intervention and target values for low-density lipoprotein (LDL) cholesterol levels in children with familial hypercholesterolemia. Design Systematic review and meta-analysis. PubMed, Medline, CINAHL and Cochrane Reviews databases from 1966 to 2007 were searched for articles reporting statin therapy in children and adolescents aged 8–18 years. Retrieved articles were screened for double-blind randomised controlled trials (RCTs… Expand
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References

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A Systematic Review and Meta-Analysis of Statin Therapy in Children With Familial Hypercholesterolemia
TLDR
The results support the notion that statin therapy in children with HeFH is safe, and even though further studies are required to assess lifelong safety, statin treatment should be considered for all children aged 8 to 18 with HeHF. Expand
Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins
TLDR
Statin therapy can safely reduce the 5-year incidence of major coronary events, coronary revascularisation, and stroke by about one fifth per mmol/L reduction in LDL cholesterol, largely irrespective of the initial lipid profile or other presenting characteristics. Expand
Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial.
TLDR
Two years of pravastatin therapy induced a significant regression of carotid atherosclerosis in children with familial hypercholesterolemia, with no adverse effects on growth, sexual maturation, hormone levels, or liver or muscle tissue. Expand
Narrative Review: Lack of Evidence for Recommended Low-Density Lipoprotein Treatment Targets: A Solvable Problem
Key Summary Points No high-quality evidence could be found that suggests that titrating lipid therapy to recommended low-density lipoprotein (LDL) cholesterol targets is superior to empiricallyExpand
Efficacy and Safety of Statin Therapy in Children With Familial Hypercholesterolemia: A Randomized, Double-Blind, Placebo-Controlled Trial With Simvastatin
TLDR
Simvastatin significantly reduced LDL cholesterol, total cholesterol, triglyceride, VLDL cholesterol, and apolipoprotein B levels and was well tolerated in children with heFH and there was no evidence of any adverse effect of simVastatin on growth and pubertal development. Expand
Statin Treatment in Children With Familial Hypercholesterolemia: The Younger, the Better
TLDR
It is shown for the first time that early initiation of statin therapy in children with familial hypercholesterolemia might be beneficial in the prevention of atherosclerosis in adolescence. Expand
Efficacy and safety of atorvastatin in children and adolescents with familial hypercholesterolemia or severe hyperlipidemia: a multicenter, randomized, placebo-controlled trial.
TLDR
Treatment with atorvastatin for 12 months was effective and safe for pediatric subjects with known familial hypercholesterolemia or severe hypercholesterololemia and was as well-tolerated as placebo. Expand
Efficacy and Safety of Lovastatin Therapy in Adolescent Girls With Heterozygous Familial Hypercholesterolemia
TLDR
Lovastatin offers an efficacious and well-tolerated treatment option for improving lipid profiles in adolescent girls with familial hypercholesterolemia and was generally safe and well tolerated. Expand
Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
TLDR
The trials confirm the benefit of cholesterol-lowering therapy in high-risk patients and support the ATP III treatment goal of low-density lipoprotein cholesterol (LDL-C) <100 mg/dL, and confirm that older persons benefit from therapeutic lowering of LDL-C. Expand
Efficacy and safety of lovastatin in adolescent males with heterozygous familial hypercholesterolemia: a randomized controlled trial.
TLDR
This study in adolescent boys with HeFH confirmed the LDL-C-reducing effectiveness of lovastatin, and comprehensive clinical and biochemical data on growth, hormonal, and nutritional status indicated no significant differences between Lovastatin and placebo over 48 weeks, although further study is required. Expand
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