Are there stereoselective electrophysiologic effects of intravenously administered (S)- or (R)-propafenone hydrochloride in patients with supraventricular tachycardia?

@article{Candinas1996AreTS,
  title={Are there stereoselective electrophysiologic effects of intravenously administered (S)- or (R)-propafenone hydrochloride in patients with supraventricular tachycardia?},
  author={Reto Candinas and H. O. Gloor and Wolfgang Lindner and Huy Riem Ha and Wolfgang Buchinger and Franz Wolfgang Amann and Ferenc Follath},
  journal={European Journal of Clinical Pharmacology},
  year={1996},
  volume={50},
  pages={185-190}
}
Objective: The electrophysiological effects of intravenously administered pure (S)- and (R)-propafenone hydrochloride has been determined for the first time in humans – 12 patients with supraventricular tachycardia. Methods: Measurements were performed before and during drug therapy. Results: (S)- and (R)-propafenone prolonged the AH interval from 82 to 107 ms and 75 to 84 ms, respectively, and significantly increased the AV nodal Wenckebach cycle length by 58 ms and 37 ms , respectively. The… CONTINUE READING
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