Are there multiple proteolytic pathways contributing to c-Fos, c-Jun and p53 protein degradation in vivo?


The c-Fos and c-Jun oncoproteins and the p53 tumor suppressor protein are short-lived transcription factors. Several catabolic pathways contribute to their degradation in vivo. c-Fos and c-Jun are thus mostly degraded by the proteasome, but there is indirect evidence that, under certain experimental/physiological conditions, calpains participate in their… (More)
DOI: 10.1023/A:1006960021281


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