Are therapeutic diets an emerging additional choice in autism spectrum disorder management?
@article{Gogou2018AreTD, title={Are therapeutic diets an emerging additional choice in autism spectrum disorder management?}, author={Maria Gogou and George Kolios}, journal={World Journal of Pediatrics}, year={2018}, volume={14}, pages={215-223} }
BackgroundA nutritional background has been recognized in the pathophysiology of autism and a series of nutritional interventions have been considered as complementary therapeutic options. [] Key MethodData sourceA systematic review was conducted by two reviewers independently. Prospective clinical and preclinical studies were considered.ResultTherapeutic diets that have been used in children with autism include ketogenic and gluten/casein-free diet. We were able to identify 8 studies conducted in animal…
28 Citations
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In this review, nutritional intervention that can be used to achieve better results in management and treatment of autism spectrum disorder is looked at.
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The state of the current clinical and experimental literature on nutritional interventions for ASD, including gluten-free and casein-free, ketogenic, and specific carbohydrate diets, as well as probiotics, polyunsaturated fatty acids, and dietary supplements are summarized.
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The neuroprotective role of a ketogenic diet in ASD is likely mediated via improvements in energy metabolism, reductions in antioxidative stress levels, control of neurotransmitters, inhibition of the mammalian target of rapamycin (mTOR) signaling pathway, and modulation of the gut microbiota.
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The development of multiple animal models of ASD to contribute to the disease mechanisms of ASD, as well as new studies from multiple disciplines to assess the behavioral pathology of ASD are discussed.
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