Are therapeutic diets an emerging additional choice in autism spectrum disorder management?

  title={Are therapeutic diets an emerging additional choice in autism spectrum disorder management?},
  author={Maria Gogou and George Kolios},
  journal={World Journal of Pediatrics},
BackgroundA nutritional background has been recognized in the pathophysiology of autism and a series of nutritional interventions have been considered as complementary therapeutic options. [] Key MethodData sourceA systematic review was conducted by two reviewers independently. Prospective clinical and preclinical studies were considered.ResultTherapeutic diets that have been used in children with autism include ketogenic and gluten/casein-free diet. We were able to identify 8 studies conducted in animal…

A Review on Nutritional and Dietary Intervention for Autism Spectrum Disorder

In this review, nutritional intervention that can be used to achieve better results in management and treatment of autism spectrum disorder is looked at.

Nutritional interventions for autism spectrum disorder.

The state of the current clinical and experimental literature on nutritional interventions for ASD, including gluten-free and casein-free, ketogenic, and specific carbohydrate diets, as well as probiotics, polyunsaturated fatty acids, and dietary supplements are summarized.

A Review of the Efficacy of the Dietary Intervention in Autism Spectrum Disorder

There is little evidence to support the use of dietary interventions for children with ASD, and further research is needed to provide up-to-date evidence.

Nutritional Supplements During Gestation and Autism Spectrum Disorder: What Do We Really Know and How Far Have We Gone?

Research based on animal models showed that choline and folic acid can have a significant impact on the expression of autism-related genes in a sex-specific manner, and the use of vitamin D and docosahexaenoic acid during gestation seem to decrease the incidence of autism in animal offspring.

Is the gluten-free and casein-free diet efficacious in the treatment of childhood autism spectrum disorder?

The identification of a hypothetical diet-related ASD phenotype may help in selecting children who could benefit from a GFCF dietary intervention, and an important consideration is that potentially ineffective therapies may imply considerable opportunity costs, with other possibly more effective treatment approaches remaining unutilized.

The Ketogenic Diet: An Answer for Autism?

The ketogenic diet is a high fat, low carbohydrate nutritional practice intended to initiate metabolic ketosis within the body, which increases mitochondrial function and can decrease the prevalence of seizures in ASD patients.

The level of intestinal protein binding fatty acids in children with autism spectrum disorders, depending on the style of nutrition

Comparing the levels of I-FABP in children with autism spectrum disorders, depending on the adherence to a gluten-free diet found children using diet therapy were found to have significantly lower intestinal permeability.

Treating autism spectrum disorder by intervening with gut microbiota.

Microbiota transplantation, including faecal microbiota transplantation (FMT), probiotics, breastfeeding, formula feeding, gluten-free and casein-free (GFCF) diet and ketogenic diet therapy, may provide satisfying effects for ASD and its related various symptoms.

A Scoping Literature Review of the Relation between Nutrition and ASD Symptoms in Children

There is currently insufficient evidence for a relation between nutrition and ASD symptoms in childhood, making it impossible to provide practical nutrition guidelines; more methodological sound research is needed.



The relationship of autism and gluten.

  • T. Buie
  • Medicine
    Clinical therapeutics
  • 2013

Supplement intervention associated with nutritional deficiencies in autism spectrum disorders: a systematic review

Current evidence for the use of supplements for correcting nutritional deficiencies in children with ASD and to improve the symptoms is little and more studies are needed.

Potential Therapeutic Use of the Ketogenic Diet in Autism Spectrum Disorders

Given that the mechanism of action of the KGD is not fully understood, caution should be exercised in ASD cases lacking a careful biochemical and metabolic characterization to avoid deleterious side effects or refractory outcomes.

Autism and Dietary Therapy

A child with autism and epilepsy who, after limited response to other interventions following her regression into autism, was placed on a gluten-free, casein-free diet, after which she showed marked improvement in autistic and medical symptoms.

Nutritional status of individuals with autism spectrum disorders: do we know enough?

This review article summarizes the research, focusing on the nutritional status of individuals with ASDs based on their anthropometric measurements, biomarkers, and dietary assessments, and shows inconsistent findings on the prevalence of overweight/obesity in comparison with typically growing children.

Elimination diets’ efficacy and mechanisms in attention deficit hyperactivity disorder and autism spectrum disorder

This review discusses an elimination diet as a treatment for attention deficit hyperactivity disorder and autism spectrum disorder, with a focus on the efficacy of the food additives exclusion diet, gluten-free/casein-free diet and oligoantigenic diet.

Gluten-free and casein-free diets in the therapy of autism

The findings of this study suggest additional effects of a gluten-free and casein-free diet on comorbid problems of autism such as gastrointestinal symptoms, concentration, and attention.