Are therapeutic diets an emerging additional choice in autism spectrum disorder management?

@article{Gogou2018AreTD,
  title={Are therapeutic diets an emerging additional choice in autism spectrum disorder management?},
  author={Maria Gogou and George Kolios},
  journal={World Journal of Pediatrics},
  year={2018},
  volume={14},
  pages={215-223}
}
BackgroundA nutritional background has been recognized in the pathophysiology of autism and a series of nutritional interventions have been considered as complementary therapeutic options. [...] Key MethodData sourceA systematic review was conducted by two reviewers independently. Prospective clinical and preclinical studies were considered.ResultTherapeutic diets that have been used in children with autism include ketogenic and gluten/casein-free diet. We were able to identify 8 studies conducted in animal…Expand
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23 Citations
Background Citations
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Methods Citations
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23 Citations

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Citation Type

A Review on Nutritional and Dietary Intervention for Autism Spectrum Disorder
In this review we will be looking at nutritional intervention that can be used to achieve better results in management and treatment of autism spectrum disorder. Eating disorders are widespread in…
Nutritional interventions for autism spectrum disorder.
TLDR
The state of the current clinical and experimental literature on nutritional interventions for ASD, including gluten-free and casein-free, ketogenic, and specific carbohydrate diets, as well as probiotics, polyunsaturated fatty acids, and dietary supplements are summarized.
A Review of the Efficacy of the Dietary Intervention in Autism Spectrum Disorder
TLDR
There is little evidence to support the use of dietary interventions for children with ASD, and further research is needed to provide up-to-date evidence.
Nutritional Supplements During Gestation and Autism Spectrum Disorder: What Do We Really Know and How Far Have We Gone?
TLDR
Research based on animal models showed that choline and folic acid can have a significant impact on the expression of autism-related genes in a sex-specific manner, and the use of vitamin D and docosahexaenoic acid during gestation seem to decrease the incidence of autism in animal offspring.
The Ketogenic Diet: An Answer for Autism?
TLDR
The ketogenic diet is a high fat, low carbohydrate nutritional practice intended to initiate metabolic ketosis within the body, which increases mitochondrial function and can decrease the prevalence of seizures in ASD patients.
The level of intestinal protein binding fatty acids in children with autism spectrum disorders, depending on the style of nutrition
TLDR
Comparing the levels of I-FABP in children with autism spectrum disorders, depending on the adherence to a gluten-free diet found children using diet therapy were found to have significantly lower intestinal permeability.
Pharmacological, non-pharmacological and stem cell therapies for the management of autism spectrum disorders: a focus on human studies.
TLDR
Interventional studies describing pharmacological and non-pharmacological treatments in ASD children and adolescents, along with stem cell-based therapies, are reviewed.
Treating autism spectrum disorder by intervening with gut microbiota.
  • Tingting Tu, Changlin Zhao
  • Medicine
    Journal of medical microbiology
  • 2021
TLDR
Microbiota transplantation, including faecal microbiota transplantation (FMT), probiotics, breastfeeding, formula feeding, gluten-free and casein-free (GFCF) diet and ketogenic diet therapy, may provide satisfying effects for ASD and its related various symptoms.
A Ketogenic Diet and the Treatment of Autism Spectrum Disorder
TLDR
The neuroprotective role of a ketogenic diet in ASD is likely mediated via improvements in energy metabolism, reductions in antioxidative stress levels, control of neurotransmitters, inhibition of the mammalian target of rapamycin (mTOR) signaling pathway, and modulation of the gut microbiota.
Equity, acceptability and feasibility of using polyunsaturated fatty acids in children and adolescents with autism spectrum disorder: a rapid systematic review
TLDR
The administration of PUFAs in children and adolescents with ASD is found to be potentially equitable, acceptable and feasible and to be viewed in light of efficacy and safety data to formulate clinical recommendations.
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References

SHOWING 1-10 OF 56 REFERENCES
The relationship of autism and gluten.
  • T. Buie
  • Medicine
    Clinical therapeutics
  • 2013
TLDR
There is insufficient evidence to support instituting a gluten-free diet as a treatment for autism, but there may be a subgroup of patients who might benefit from a gluten -free diet, but the symptom or testing profile of these candidates remains unclear.
A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder
TLDR
A modified gluten-free ketogenic diet with supplemental MCT is a potentially beneficial treatment option to improve the core features of autism spectrum disorder and warrants further investigation.
Ketogenic diets improve behaviors associated with autism spectrum disorder in a sex-specific manner in the EL mouse
TLDR
Results in female mice showed that a less strict, more clinically-relevant diet formula was equally effective in improving sociability and reducing repetitive behavior, and added to the growing number of studies suggesting that ketogenic and related diets may provide significant relief from the core symptoms of autism spectrum disorder.
Supplement intervention associated with nutritional deficiencies in autism spectrum disorders: a systematic review
TLDR
Current evidence for the use of supplements for correcting nutritional deficiencies in children with ASD and to improve the symptoms is little and more studies are needed.
The gluten-free, casein-free diet in autism: an overview with clinical implications.
  • J. Elder
  • Medicine
    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
  • 2008
TLDR
An overview of ASD and the GFCF diet, a summary and critique of current research findings, recommendations for future research, and practical advice for families to use in deciding if a trial of the G FCF diet is in the best interest of their child and family are provided.
Potential Therapeutic Use of the Ketogenic Diet in Autism Spectrum Disorders
TLDR
Given that the mechanism of action of the KGD is not fully understood, caution should be exercised in ASD cases lacking a careful biochemical and metabolic characterization to avoid deleterious side effects or refractory outcomes.
Autism and Dietary Therapy
TLDR
A child with autism and epilepsy who, after limited response to other interventions following her regression into autism, was placed on a gluten-free, casein-free diet, after which she showed marked improvement in autistic and medical symptoms.
Nutritional status of individuals with autism spectrum disorders: do we know enough?
TLDR
This review article summarizes the research, focusing on the nutritional status of individuals with ASDs based on their anthropometric measurements, biomarkers, and dietary assessments, and shows inconsistent findings on the prevalence of overweight/obesity in comparison with typically growing children.
Elimination diets’ efficacy and mechanisms in attention deficit hyperactivity disorder and autism spectrum disorder
TLDR
This review discusses an elimination diet as a treatment for attention deficit hyperactivity disorder and autism spectrum disorder, with a focus on the efficacy of the food additives exclusion diet, gluten-free/casein-free diet and oligoantigenic diet.
A pilot study to evaluate nutritional influences on gastrointestinal symptoms and behavior patterns in children with Autism Spectrum Disorder.
TLDR
This study provides evidence that the adapted FFQ is an effective tool for evaluating adherence to a GFCF diet and elucidate the gut-brain relationship in children with ASD.
...
1
2
3
4
5
...