Are the structure and function of an enzyme the same in aqueous solution and in the wet crystal?

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@article{Rossi1970AreTS, title={Are the structure and function of an enzyme the same in aqueous solution and in the wet crystal?}, author={Gian Luigi Rossi and Sidney A. Bernhard}, journal={Journal of molecular biology}, year={1970}, volume={49 1}, pages={85-91} }