Are the clinical and pathological features of differentiated thyroid carcinoma really changed over the last 35 years? Study on 4187 patients from a single Italian institution to answer this question.

@article{Elisei2010AreTC,
  title={Are the clinical and pathological features of differentiated thyroid carcinoma really changed over the last 35 years? Study on 4187 patients from a single Italian institution to answer this question.},
  author={R. Elisei and E. Molinaro and L. Agate and V. Bottici and L. Masserini and C. Ceccarelli and F. Lippi and L. Grasso and F. Basolo and G. Bevilacqua and P. Miccoli and G. Di Coscio and P. Vitti and F. Pacini and A. Pinchera},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2010},
  volume={95 4},
  pages={
          1516-27
        }
}
BACKGROUND In the last decades, a marked increased prevalence of differentiated thyroid cancer (DTC) has been observed worldwide. The aim of this study was to evaluate the changing features of DTC referred to our institution between 1969 and 2004. METHODS Clinical and pathological features and prognostic factors were analyzed in 4187 DTC patients, subdivided into two groups: group 1 (n = 1215) and group 2 (n = 2972) diagnosed before and after 1990, respectively. RESULTS Group 2 showed an… Expand
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