Are sirtuins viable targets for improving healthspan and lifespan?

@article{Baur2012AreSV,
  title={Are sirtuins viable targets for improving healthspan and lifespan?},
  author={Joseph A. Baur and Zoltan Ungvari and Robin K. Minor and David G. Le Couteur and Rafael C. de Cabo},
  journal={Nature Reviews Drug Discovery},
  year={2012},
  volume={11},
  pages={443-461}
}
Although the increased lifespan of our populations illustrates the success of modern medicine, the risk of developing many diseases increases exponentially with old age. Caloric restriction is known to retard ageing and delay functional decline as well as the onset of disease in most organisms. Studies have implicated the sirtuins (SIRT1–SIRT7) as mediators of key effects of caloric restriction during ageing. Two unrelated molecules that have been shown to increase SIRT1 activity in some… CONTINUE READING
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