Are sirtuins markers of ovarian aging?

  title={Are sirtuins markers of ovarian aging?},
  author={Jin-jin Zhang and Li Fang and Zhiyong Lu and Jiaqiang Xiong and Meng Da Wu and Liangyan Shi and Aiyue Luo and Shixuan Wang},
  volume={575 2 Pt 3},
Sirtuins, a family of nicotinamide adenine dinucleotide (NAD)-dependent deacetylases that play diverse roles in regulating metabolism, cell proliferation, and genome stability, have been implicated in mammalian aging and age-related diseases, including cancers, metabolic disorders, and neurodegenerative diseases. Ovarian aging is thought to be characterized by a gradual decrease in both the number of follicles and the quality of oocytes. Ovarian reserve is indicated by the number of primordial… CONTINUE READING
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