Are scoring functions in protein-protein docking ready to predict interactomes? Clues from a novel binding affinity benchmark.

@article{Kastritis2010AreSF,
  title={Are scoring functions in protein-protein docking ready to predict interactomes? Clues from a novel binding affinity benchmark.},
  author={Panagiotis L. Kastritis and Alexandre M. J. J. Bonvin},
  journal={Journal of proteome research},
  year={2010},
  volume={9 5},
  pages={2216-25}
}
The design of an ideal scoring function for protein-protein docking that would also predict the binding affinity of a complex is one of the challenges in structural proteomics. Such a scoring function would open the route to in silico, large-scale annotation and prediction of complete interactomes. Here we present a protein-protein binding affinity benchmark consisting of binding constants (K(d)'s) for 81 complexes. This benchmark was used to assess the performance of nine commonly used scoring… CONTINUE READING

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