Are rhinoviruses implicated in the pathogenesis of sinusitis and chronic rhinosinusitis exacerbations? A comprehensive review

  title={Are rhinoviruses implicated in the pathogenesis of sinusitis and chronic rhinosinusitis exacerbations? A comprehensive review},
  author={Usmaan Basharat and Mazen Marwan Aiche and Marianne M Kim and Maheep Sohal and Eugene H Chang},
  journal={International Forum of Allergy \& Rhinology},
  pages={1159 - 1188}
Rhinovirus (RV) infections are the most common cause of viral upper respiratory infections (URIs), and in the majority of persons they are self‐limiting. However, in others, viral URIs can progress to bacterial sinusitis and induce chronic rhinosinusitis (CRS) exacerbations. 

RV‐C infections result in greater clinical symptoms and epithelial responses compared to RV‐A infections in patients with CRS

Human rhinovirus (HRV) is the most frequent cause of the common cold and acute viral rhinosinusitis. Traditionally, HRV identification was performed using culture-based, biochemical and serologic

Current Understanding of the Acute Exacerbation of Chronic Rhinosinusitis

There have been significant advances in understanding the etiology and immunological feathers of acute CRS exacerbation, Nevertheless, consensus definition, diagnostic criterion, biomarkers to differentiate acute C RS exacerbation from CRS, assessment of disease severity, and evidence-based treatment options are still lacking.

Detection of Respiratory Viruses among Chronic Rhinosinusitis Patients Attending Zagazig University Hospitals

The co-presence of CRS with AR and/or asthma suggests their relationship to disease progression, and respiratory viruses are prevalent with CRS.

International consensus statement on allergy and rhinology: rhinosinusitis 2021

The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and

Rhinovirus-induced anti-viral interferon secretion is not deficient and not delayed in sinonasal epithelial cells of patients with chronic rhinosinusitis with nasal polyp

The production of RV16-induced antiviral interferons is not deficient or delayed in inflammatory epithelial cells from CRS patients with nasal polyps, and expression levels of viperin, Mx, OAS, TLR3, RIG-I, MDA5, phospho-NFκB, andospho-IRF3 showed similar patterns in both groups of epithel cells.

Symptomic Mimicry Between SARS-CoV-2 and the Common Cold Complex

The reason why so many unrelated pathogens cause similar symptoms may correspond to the reasons that drove the evolution of the ‘warning’ wasp-like colouration in various insect species.

European Position Paper on Rhinosinusitis and Nasal Polyps 2020.

The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012 and addresses areas not extensively covered in EPOS2012 such as paediatric CRS and sinus surgery.

The Expression of ephrinA1/ephA2 Receptor Increases in Chronic Rhinosinusitis and ephrinA1/ephA2 Signaling Affects Rhinovirus-Induced Innate Immunity in Human Sinonasal Epithelial Cells

A novel role of ephrinA1/ephA2 signaling in antiviral innate immune response in sinonasal epithelium is described, suggesting their participation in RV-induced development and exacerbations of CRS.

Rhinologic and skull‐base surgery: an evidence‐based reevaluation

  • D. Kennedy
  • Medicine
    International forum of allergy & rhinology
  • 2019
This issue of the Journal shows conclusively that the incidence of intracranial complications is markedly reduced with surgical closure, and an inverse relationship between body mass index (BMI) and the risk of complications is found, a finding which is interpreted as being supportive of the conventional wisdom that low-flow CSF leaks are associated with a higher risk of complication.

The Effect of Plasma Low-temperature Radiofrequency Ablation Combined with Nasal Endoscopy on Olfactory Function and Serum Inflammatory Mediators in Patients with Chronic Sinusitis*

  • Biology
  • 2020
摘要目的:探讨等离子低温射频消融术联合鼻内镜对慢性鼻窦炎(CRS)患者嗅觉功能及血清炎症介质的影响。方法:选取 2016 年 3月 ~2018年 7月期间我院收治的 CRS患者 127例,根据手术方式的不同将患者分为 A组(n=62,鼻内镜手术)和 B组(n=65, 等离子低温射频消融术联合鼻内镜手术),术后随访 1年,比较两组患者临床疗效、症状评分、嗅觉功能、血清炎症介质及并发症



Human rhinovirus serotypes in the nasal washes and mucosa of patients with chronic rhinosinusitis

This research aimed to investigate whether any specific human rhinovirus serotype is more common in the mucosa of CRS patients, and to find any defining clinical characteristics, according to the various HRV serotypes.

Rhinovirus infection in murine chronic allergic rhinosinusitis model

Patients with chronic rhinosinusitis (CRS) commonly experience aggravation of their symptoms after viral upper respiratory infection (URI) and in vivo studies investigating the effect of RV infection on CRS are lacking.

Respiratory viral infection in the chronic persistent phase of chronic rhinosinusitis

The aim of this study was to explore the prevalence of respiratory viruses in the chronic status of CRS and the role of respiratory viral infection in the pathogenesis of chronic rhinosinusitis.

Is chronic rhinosinusitis caused by persistent respiratory virus infection?†, ‡, §

This work sought to determine whether respiratory viruses could be detected within the sinonasal mucosa of CRS patients using polymerase chain reaction (PCR) techniques.

Rhinitis in the first 18 months of life: Exploring the role of respiratory viruses

  • A. HardjojoA. Goh B. Lee
  • Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2015
This study aimed to evaluate rhinitis in the first 18 months of life, its link with other atopic manifestations and the role of respiratory viruses.

Bacteria in the nose of young adults during wellness and rhinovirus colds: detection by culture and microarray methods in 100 nasal lavage specimens

Patients with viral respiratory infections/viral rhinitis/common colds are often treated with antibiotic; however, there is little information on whether or how bacterial microbiota in the nose and

Impact of Respiratory Virus Infections in Exacerbation of Acute and Chronic Rhinosinusitis

The potential of harnessing existing antiviral strategies to prevent ARS and CRS exacerbation is explored, especially with improved viral diagnostic tools to guide accurate prescription of antivirals against causative respiratory viruses.

Immunological profiling in chronic rhinosinusitis with nasal polyps reveals distinct VEGF and GM‐CSF signatures during symptomatic exacerbations

  • R. DivekarS. Samant H. Kita
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2015
The mechanisms and immune pathways associated with chronic rhinosinusitis (CRS) are not fully understood. Immunological changes during acute exacerbation of CRS may provide valuable clues to the

Rhinovirus enhances various bacterial adhesions to nasal epithelial cells simultaneously

The effect of rhinovirus infection on the expression of cell adhesion molecules and bacterial adherence to primary human nasal epithelial cells is investigated.

Prevalence of Rhinovirus and Respiratory Syncytial Virus Among Patients With Chronic Rhinosinusitis

This study showed the high prevalence of rhinovirus and respiratory syncytial virus in patients with CRS, a common disease with negative effects on the quality of patients’ lives.