Are renal reference intervals required when screening for plasma cell disorders with serum free light chains and serum protein electrophoresis?

Abstract

Renal impairment and polyclonal hypergammaglobulinemia may abnormally increase the serum free light chain (sFLC) ratio, giving false-positive results with current reference intervals. We measured sFLCs with concomitant serum protein electrophoresis (SPEP) and urine protein electrophoresis (UPEP) in 281 patients. Results were interpreted relative to renal… (More)
DOI: 10.1309/AJCPR2M4EUYNHLGM

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