Are protein folds atypical?

  title={Are protein folds atypical?},
  author={Hui Li and Chao Tang and Ned S. Wingreen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 9},
Protein structures are a very special class among all possible structures. It has been suggested that a "designability principle" plays a crucial role in nature's selection of protein sequences and structures. Here, we provide a theoretical base for such a selection principle, using a simple model of protein folding based on hydrophobic interactions. A… CONTINUE READING