Are progestins really necessary as part of a combined HRT regimen?

@article{Sturdee2013ArePR,
  title={Are progestins really necessary as part of a combined HRT regimen?},
  author={D. Sturdee},
  journal={Climacteric},
  year={2013},
  volume={16},
  pages={79 - 84}
}
Abstract For many years it has been perceived wisdom that hormone replacement therapy for women with a uterus should include a progestin to prevent the proliferative effects of estrogen on the endometrium and endometrial cancer. But, with the reports from the Women's Health Initiative (WHI) and Million Women Study indicating that such regimens are associated with an increased risk of breast cancer, whereas unopposed estrogen may not increase this risk, or even reduce it, it is pertinent to… Expand

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