Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?

@article{Sindrup1993ArePM,
  title={Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?},
  author={S\oren Hein Sindrup and Lars Poulsen and Kim Br\osen and Lars Arendt-Nielsen and Lars Freng Gram},
  journal={Pain},
  year={1993},
  volume={53},
  pages={335-339}
}
It has recently been shown that O-demethylation of the opioid drug codeine to morphine depends on the sparteine/debrisoquine oxygenase (CYP2D6) which in man exhibits genetic polymorphism. Morphine may be an endogenously formed substance in mammalians. Therefore, it may be hypothesized that the final step in an endogenous synthesis of morphine from codeine also depends on CYP2D6. CYP2D6, which is present in the liver and presumably also in the brain, is not expressed in subjects who are poor… CONTINUE READING

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