Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL.

@article{Pierroz2010AreON,
  title={Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL.},
  author={Dominique D. Pierroz and Nicolas Bonnet and P. A. J. Baldock and Michael Stuart Ominsky and Marina Stolina and Paul J. Kostenuik and Serge Ferrari},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 36},
  pages={28164-73}
}
PTH stimulates osteoblastic cells to form new bone and to produce osteoblast-osteoclast coupling factors such as RANKL. Whether osteoclasts or their activity are needed for PTH anabolism remains uncertain. We treated ovariectomized huRANKL knock-in mice with a human RANKL inhibitor denosumab (DMAb), alendronate (Aln), or vehicle for 4 weeks, followed by co-treatment with intermittent PTH for 4 weeks. Loss of bone mass and microarchitecture was prevented by Aln and further significantly improved… CONTINUE READING