Are non-functional, unfolded proteins ('junk proteins') common in the genome?

@article{Lovell2003AreNU,
  title={Are non-functional, unfolded proteins ('junk proteins') common in the genome?},
  author={Simon C. Lovell},
  journal={FEBS letters},
  year={2003},
  volume={554 3},
  pages={237-9}
}
It has recently been shown that many proteins are unfolded in their functional state. In addition, a large number of stretches of protein sequences are predicted to be unfolded. It has been argued that the high frequency of occurrence of these predicted unfolded sequences indicates that the majority of these sequences must also be functional. These sequences tend to be of low complexity. It is well established that certain types of low-complexity sequences are genetically unstable, and are… CONTINUE READING