Are nicotinic acetylcholine receptors coupled to G proteins?

@article{Kabbani2013AreNA,
  title={Are nicotinic acetylcholine receptors coupled to G proteins?},
  author={Nadine Kabbani and Jacob C. Nordman and Brian A Corgiat and Daniel Veltri and Amarda Shehu and Victoria A. L. Seymour and David John Adams},
  journal={BioEssays},
  year={2013},
  volume={35}
}
It was, until recently, accepted that the two classes of acetylcholine (ACh) receptors are distinct in an important sense: muscarinic ACh receptors signal via heterotrimeric GTP binding proteins (G proteins), whereas nicotinic ACh receptors (nAChRs) open to allow flux of Na+, Ca2+, and K+ ions into the cell after activation. Here we present evidence of direct coupling between G proteins and nAChRs in neurons. Based on proteomic, biophysical, and functional evidence, we hypothesize that binding… 
Connecting the dots between G proteins, G protein coupled receptors, and neuronal nicotinic acetylcholine receptors (Comment on DOI 10.1002/bies.201300082)
  • E. Hawrot
  • Biology, Chemistry
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2013
TLDR
A testable hypothesis is generated that certain amino acids in the major intracellular loop of neuronal nicotinic acetylcholine receptors form the binding site for G proteins, which is consistent with previous proteomic studies of mouse brain nAChRs and their interacting proteomes.
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TLDR
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TLDR
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TLDR
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