Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats.

@article{Lscher2003AreNN,
  title={Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats.},
  author={Wolfgang L{\"o}scher and Heidrun Potschka and Piotr Wlaź and Wojciech Danysz and Christopher G. Parsons},
  journal={European journal of pharmacology},
  year={2003},
  volume={466 1-2},
  pages={99-111}
}
Altered function of neuronal nicotinic acetylcholine receptors in the brain has recently been associated with an idiopathic form of partial epilepsy, suggesting that functional alterations of these receptors can be involved in the processes leading to epileptic seizures. Thus, nicotinic acetylcholine receptors may form a novel target for antiepileptic drug development. In the present study, various nicotinic acetylcholine receptor antagonists, including novel amino-alkyl-cyclohexane derivatives… CONTINUE READING

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