Are natural proteins special? Can we do that?

@article{Hecht2018AreNP,
  title={Are natural proteins special? Can we do that?},
  author={Michael H Hecht and Shlomo Zarzhitsky and Christina Karas and Sarangan Chari},
  journal={Current opinion in structural biology},
  year={2018},
  volume={48},
  pages={124-132}
}
Natural proteins represent a minuscule fraction of possible sequence space. These very rare sequences display remarkable properties: They fold into many different stable structures, and perform a wide range of complex biological functions. These two considerations-rarity and functionality-may suggest that natural proteins are somehow special. Is this true… CONTINUE READING