Are mu-opioid receptor polymorphisms important for clinical opioid therapy?

  title={Are mu-opioid receptor polymorphisms important for clinical opioid therapy?},
  author={J{\"o}rn L{\"o}tsch and Gerd 7 Geisslinger},
  journal={Trends in molecular medicine},
  volume={11 2},
Mutations in the mu-opioid receptor--the primary site of action of opioid analgesics--are candidates for the variability of clinical opioid effects. This has been substantiated by recent advances in genetic research. A common mu-opioid receptor polymorphism was associated with higher demands for alfentanil or morphine for pain relief. It also decreased the potency of morphine for pupil constriction and experimental analgesia, but its molecular mechanisms are unclear. Another opioid receptor… CONTINUE READING

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