Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?

@inproceedings{Kumar2012AreMM,
  title={Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?},
  author={R. V. M. S. S. Kiran Kumar and Paul S Foster},
  booktitle={Front. Physio.},
  year={2012}
}
Whether mouse models of chronic asthma can be used to investigate the relationship between airway inflammation/remodeling and airway hyper-responsiveness (AHR) is a vexed question. It raises issues about the extent to which such models replicate key features of the human disease. Here, we review some of the characteristic pathological features of human asthma and their relationship to AHR and examine some limitations of mouse models that are commonly used to investigate these relationships. We… CONTINUE READING