Are metabolic oscillations responsible for normal oscillatory insulin secretion?

@article{Tornheim1997AreMO,
  title={Are metabolic oscillations responsible for normal oscillatory insulin secretion?},
  author={Keith Tornheim},
  journal={Diabetes},
  year={1997},
  volume={46 9},
  pages={1375-80}
}
Normal insulin secretion is oscillatory in vivo and in vitro, with a period of approximately 5-10 min. The mechanism of generating these oscillations is not yet established, but a metabolic basis seems most likely for glucose-stimulated secretion. The rationale is that 1) spontaneous oscillatory operation of glycolysis is a well-established phenomenon; 2) oscillatory behavior of glycolysis involves oscillations in the ATP/ADP ratio, which can cause alternating opening and closing of ATP… CONTINUE READING