Are insulin autoantibodies markers for insulin-dependent diabetes mellitus?

  title={Are insulin autoantibodies markers for insulin-dependent diabetes mellitus?},
  author={Mark A Atkinson and Noel K. Maclaren and William Riley and William Edward Winter and Diann D Fisk and Rebecca P Spillar},
  volume={35 8},
Recent studies have shown that insulin autoantibodies occur in patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM) before exogenous insulin treatment. Our study was designed to test the hypothesis that insulin autoantibodies, like cytoplasmic islet cell antibodies (ICAs), can identify individuals with ongoing autoimmune beta-cell destruction and increased risk of IDDM development. Insulin autoantibodies detected by use of a radioligand-binding assay were found in 1.4% of… CONTINUE READING


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