Are in vitro estimates of cell diffusivity and cell proliferation rate sensitive to assay geometry?

@article{Treloar2014AreIV,
  title={Are in vitro estimates of cell diffusivity and cell proliferation rate sensitive to assay geometry?},
  author={Katrina K. Treloar and Matthew J. Simpson and D. L. Sean McElwain and Ruth E. Baker},
  journal={Journal of theoretical biology},
  year={2014},
  volume={356},
  pages={71-84}
}
Cells respond to various biochemical and physical cues during wound-healing and tumour progression. in vitro assays used to study these processes are typically conducted in one particular geometry and it is unclear how the assay geometry affects the capacity of cell populations to spread, or whether the relevant mechanisms, such as cell motility and cell proliferation, are somehow sensitive to the geometry of the assay. In this work we use a circular barrier assay to characterise the spreading… CONTINUE READING
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