Are histones, tubulin, and actin derived from a common ancestral protein?

  title={Are histones, tubulin, and actin derived from a common ancestral protein?},
  author={John C. Gardiner and Peter Mcgee and Robyn L. Overall and Jan Marc},
Summary.Histones and the cytoskeletal components tubulin and actin all act as thermal ratchets, using the energy present in Brownian motion to do work. All three also bind to nucleotides. Here we suggest that histones, tubulin, and actin derive from a common ancestral protein. There is some sequence similarity between histone 2A and the bacterial tubulin homologue FtsZ. Histones and actin also share some sequence similarity in the nucleotides and at phosphate-binding sites. Thus, actin and… 

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