Are gap junction membrane plaques implicated in intercellular vesicle transfer?

  title={Are gap junction membrane plaques implicated in intercellular vesicle transfer?},
  author={Wouterus T. M. Gruijters},
  journal={Cell Biology International},

Dynamic changes in protein interaction between AKAP95 and Cx43 during cell cycle progression of A549 cells

It is shown that A-kinase anchoring protein 95 (AKAP95) and connexin 43 (Cx43) dynamically interact during cell cycle progression of lung cancer A549 cells to regulate multiple biological processes.

Transsynaptic modality codes in the brain: possible involvement of synchronized spike timing, microRNAs, exosomes and epigenetic processes

The possibility that the afferent neuron at the neuromuscular junction carries a cargo of Wg and Evi, which are large molecular transsynaptic signaling agents (LMTSAs), which represents a mechanism for information transfer involving the postsynaptic neuron as a whole is explored.

Integrin-Linked Kinase Inactives the Wnt Pathway through Connexin

It is demonstrated that integrin-linked kinase (ILK) plays a critical role in the suppression of the Wnt pathway via decreasing Wnt3a-induced stabilization of β-catenin, which leaded to the block of the functional gap-junctional intercellular communications (GJIC).



Structural correlates of gap junction permeation.

Intercellular communication between epithelial and fiber cells of the eye lens.

Analysis of fluorescence confocal microscopy and freeze-fracture analysis of epithelial and fiber cells of the embryonic chicken lens indicates the presence of a low-resistance pathway connecting these cell types that is not mediated by classical gap junctions.

Formation, distribution and dissociation of intercellular junctions in the lens.

A dynamic aspect of lens intercellular junctions is demonstrated and it is shown that they are positioned in a precise fashion, possibly in association with other membrane or cytoskeletal components.

A non-connexon protein (MIP) is involved in eye lens gap-junction formation.

Observation of domain-specific interactions of MIP with forming gap junctions and ball and socket domains suggests that MIP may be involved in the formation of close membrane appositions.

Spatial differences in gap junction gating in the lens are a consequence of connexin cleavage.

Immunolocalization of MP70 in lens fiber 16-17-nm intercellular junctions

In freeze-fracture replicas with adherent cortical fiber membranes, MP70 was immunolocalized in the junctional plaques which closely resemble the gap junctions in other tissues and is likely to be associated with intercellular communication in the lens.


Acetone does not cause any detectable change in the structure of the zonula occludens, but the occluding junction becomes leaky to lanthanum following acetone treatment, and the effects of other reagents on the junctions are reported.

Lens metabolic cooperation: a study of mouse lens transport and permeability visualized with freeze-substitution autoradiography and electron microscopy

The permeability results suggest that the lens cells are capable of metabolic cooperation, mediated by an extensive gap junction network, and this result is subject to species variation.

Ultrastructural, biochemical, and immunologic evidence of receptor-mediated endocytosis in the crystalline lens.

The lens epithelium is essentially the basal layer of the crystalline lens of the eye, an uncommon stratified epithelium. Ions and metabolites present in the aqueous humor gain access to the lens

Processing of the gap junction protein connexin50 in the ocular lens is accomplished by calpain.

Two closely spaced calpain cleavage sites were identified in the Cx50 molecule which were located carboxy-terminal from the predicted exit of the fourth transmembrane spanning segment by 62 or 72 amino acid residues, respectively.