Are estrogens of import to primate/human ovarian folliculogenesis?

@article{Palter2001AreEO,
  title={Are estrogens of import to primate/human ovarian folliculogenesis?},
  author={Steven F. Palter and Adriano Bueno Tavares and Ariel Hourvitz and Johannes D. Veldhuis and Eli Y Adashi},
  journal={Endocrine reviews},
  year={2001},
  volume={22 3},
  pages={
          389-424
        }
}
The notion that estrogens play a meaningful role in ovarian folliculogenesis stems from a large body of in vitro and in vivo experiments carried out in certain rodent models, (e.g., rats) wherein the stimulatory role of estrogen on granulosa cell growth and differentiation is undisputed. However, evidence derived from these polyovulatory species may not be readily generalizable to the monoovulatory subhuman primates, let alone the human. Only recently, significant observations on the ovarian… CONTINUE READING
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