Are circulating metabolites important in pharmacokinetic drug-drug interactions? A retroanalysis of clinical data.

@article{Zhao2014AreCM,
  title={Are circulating metabolites important in pharmacokinetic drug-drug interactions? A retroanalysis of clinical data.},
  author={Yuan-Sheng Zhao and Feng Chen and Li Li},
  journal={Current drug metabolism},
  year={2014},
  volume={15 8},
  pages={767-90}
}
Pharmacokinetic (PK) drug-drug interactions (DDIs) give rise to adverse events and/or reduced efficacy. Comprehensive, systematic and mechanistic approaches have been applied in the evaluation, propagation and management of the interaction potential of a new drug during its development and clinical use. However, the role of drug metabolite(s) in DDIs was not extensively investigated. Recently, regulatory bodies have proposed that metabolites at ≥25% of the parent drug's area under the time… CONTINUE READING

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