Are chitosan formulations mucoadhesive in the human small intestine? An evaluation based on gamma scintigraphy.

@article{Skkinen2006AreCF,
  title={Are chitosan formulations mucoadhesive in the human small intestine? An evaluation based on gamma scintigraphy.},
  author={Mia S S{\"a}kkinen and Janne Marvola and Hanna Kanerva and Kai Lindevall and Aapo Ahonen and Martti L. A. Marvola},
  journal={International journal of pharmaceutics},
  year={2006},
  volume={307 2},
  pages={285-91}
}
Rapid passage through the proximal intestine can result in the low bioavailability of a drug substance with site-specific absorption characteristics in the upper gastrointestinal tract. To overcome this, there is increasing interest in developing gastro-retentive formulations and/or formulations that linger in the proximal parts of the small intestine, e.g. by using mucoadhesive polymers as excipients in formulations. In our recent study, we used neutron activation-based gamma scintigraphy to… CONTINUE READING
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