Are certain multicenter randomized clinical trial structures misleading clinical and policy decisions?

@article{Kraemer2005AreCM,
  title={Are certain multicenter randomized clinical trial structures misleading clinical and policy decisions?},
  author={Helena C. Kraemer and Thomas N Robinson},
  journal={Contemporary clinical trials},
  year={2005},
  volume={26 5},
  pages={518-29}
}
Multicenter studies involving randomized clinical trials (RCTs) may have different structures. We discuss four general types. The first two, an "ideal" multicenter RCT and decentralized multicenter collaborative RCTs, we feel are, in different circumstances, highly recommended approaches. The other two, the multicenter RCT that ignores site differences and centralized multicenter collaborative RCTs, we argue, are not only not cost-effective but may also produce misleading results, thus impeding… CONTINUE READING